教育经历:

1992，博士学位，微生物学系，爱尔兰国立大学科克学院；
1984，学士学位，分子生物学专业，中国科学技术大学生物系；

工作经历:

1999.7-至今，教授，永利官网
1994.8-1999.6，副教授，永利官网
1993，博士后，法国巴斯德研究所分子生物学部
1991-1992，Research Scientist，爱尔兰Bio-Research Ireland Food Biotechnology Center
1986，访问学者，德国比勒费尔德大学遗传学系
1984-1985，实习研究员，中科院植物研究所固氮研究室

社会服务工作:

2020-2024，国家重点研发计划《合成生物学专项》“高效生物固氮回路的设计与系统优化”项目首席科学家
2010–2014，国家“973”重大基础研究计划生物固氮项目首席科学家
2004，第十四届国际固氮大会主席
2002–2006，国家“973”重大基础研究计划生物固氮项目首席科学家
1995.10-2002.8，永利官网副院长

荣誉奖励:

1999年国家杰出青年基金获得者

杂志任职:

2021-2014, Editorial Board Member with Current Opinion in Microbiology 2015-now, Editorial Board Member with Research in Microbiology

      本实验室主要兴趣在于：　　　　
　　多年来，本实验室的工作得到国际同行的认可。主要得到国家自然科学基金、国家科技部“863”、“973”项目基金、国家教育部基金资助、中法先进合作项目、Human Frontier Science Program等项目资助。主要工作包括：大肠杆菌及相关细菌中的基因调控网络，尤其是碳代谢和氮代谢的调控偶联；大肠杆菌及相关细菌中的基因调控机理；植物与微生物相互作用的分子生物学及功能基因组学研究；生物修复领域的研究（功能基因的分离）；合成生物学及生物固氮；大肠杆菌定量生物学研究等。取得的主要成就有，发现原核基因表达调控中碳代谢及氮代谢之间的新的偶联作用及其分子机理；发现DNA物理特性参与基因表达调控（该成果被国际知名学术网站Faculty of 1000 推荐）；提出了激活蛋白－启动子DNA－σ54-RNA聚合酶所形成的激活复合体的“三明治”结构模型（该成果被国际知名学术网站Faculty of 1000 推荐；使用合成生物学方法，我们使用T7 RNA聚合酶表达系统替代原有的σ54 RNA聚合酶对固氮基因簇的转录调控，绕开了原有固氮基因簇对转录调控系统中14种调控蛋白的依赖，为最终实现固氮基因向真核系统的转移打下坚实的基础；以肺炎克氏杆菌钼铁固氮基因簇为底盘，成功的在大肠杆菌中构建了杂合的铁铁固氮酶体系，从而在不损失酶活的前提下，成功构建了杂合的只含有10个结构基因的最小铁铁固氮酶体系（Yang et al. 2014，PNAS）；证明来源于植物叶绿体和根部白体的电子传递链模块能够功能替代钼铁及铁铁固氮酶系统中负责电子传递的原始模块，提供底物还原所需的还原力的工作（Yang and Xie et al. 2017, PNAS。该论文被PNAS期刊推荐为“From the cover”封面文章）；以及将极其复杂的需要十几个甚至几十个基因协同表达的钼铁固氮酶系统简化为五个编码Polyprotein的巨型基因，并证明其高活性可支持大肠杆菌以氮气作为唯一氮源生长的工作（Yang and Xie et al. 2018, PNAS。该论文被PNAS期刊推荐为“From the cover”封面文章），以上研究具有里程碑式的意义,为最终实现固氮基因向真核系统的转移打下坚实的基础。

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